“CSU is a challenging disease because of its chronic, spontaneous, and unpredictable nature. There’s no specific trigger, so even if we put a person with CSU in a bubble and didn’t expose them to external factors, they would still experience a flare-up,” says Dr. Gupta, who sees patients with CSU on a daily basis. “So, rather than documenting what you ate or wore before a flare-up, what you can do is document how it’s impacting your life, any lifestyle changes you’ve tried, and talk to your doctor. You don’t have to simply live with chronic hives — ask for their help in finding relief, and don’t hesitate to seek a second opinion, if needed.”